Personally, I cut each one into smaller pieces. Following a recent surgery I had, I took half at night and it helped with the pain. This was especially good for me considering that I hate taking pain medication.
The effects would kick in about ninety-minutes after taking a dose for me, lasting about four hours each time. I personally enjoyed the product and would consider purchasing again. If you're ever in the Michigan area, where you're the most likely to find a bag, go ahead and pick one up.